Maurizio belgiovine biography examples
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Abstract
Simple Summary
Desmoplastic small round cell tumor is a rare neoplasm with extremely aggressive behavior. Despite the multimodal treatment for newly diagnosed patients with chemotherapy, cytoreductive surgery and radiation, the cure rate is still low. For relapsed or progressive disease, there is limited data regarding second and third-line therapies. Novel agents have shown only modest activity. Recent molecular changes have been identified in this disease and this opens opportunities to be explored in future clinical trials.
Abstract
Desmoplastic small round cell tumor (DSRCT) is an extremely rare, aggressive sarcoma affecting adolescents and young adults with male predominance. Generally, it originates from the serosal surface of the abdominal cavity. The hallmark characteristic of DSRCT is the EWSR1–WT1 gene fusion. This translocation up-regulates the expression of PDGFRα, VEGF and other proteins related to tumor and vascular cell proliferation. Current management of DSRCT includes a combination of chemotherapy, radiation and aggressive cytoreductive surgery plus intra-peritoneal hyperthermic chemotherapy (HIPEC). Despite advances in multimodal therapy, outcomes remain poor since the majority of patients present disease recurrence and die within three years. T
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Full Cast & Crew
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Eye on Africa
Photo by Richard Howard
As she prepares to retire after 22 years in the Africana Studies department, Professor Filomina Steady isn’t slowing down. She has a new book, The African Diaspora Returns Home, in the pipeline, and her research remains very much on her mind.
How has Wellesley changed in the years you’ve been here?
I have seen a change from a strictly disciplinary emphasis to an appreciation for multidisciplinary approaches. … [M]ost disciplines cover the social sciences and the humanities, which are basically fields of integration of society and humanity rather than separation. I think it will be more difficult in the future to fragment reality into rigidly defined disciplinary lineups.
What will you miss about this place?
I will miss everyone, but my students most of all. I will also miss my valuable and hard-working faculty colleagues and sharing ideas with them. I am particularly impressed by the ones in Africana Studies and our newly recruited colleagues, who hold a lot of promise for a multidisciplinary department that is opening new spaces for theoretical and methodological approaches. These approaches centralize the contribution of people of Africa and the Diaspora to human history, the arts, and the sciences.